Yeah, the amp and speakers look nice for the price. I had a Cambridge CXA60 about 10 or so years back, and I quite liked it. I know their AXA gets a lot of love from reviewers and on forums and such. My only concern is that it's only 35 watts per channel. That's not much unless you're buying sensitive speakers. You may want to look into another Cambridge up the ladder or perhaps something like the Yamaha A-S301 or 501, or the Denon PMA-600. Those should all be sub-500, and all offer a lot more power. These are popular amps in that range off the top of my head, but surely there are others. But granted, for the small bookshelf speakers, the 35-watter would be fine. But you mentioned a big room and possibly floorstanders in the future, so that's certainly something to think about.
If you really like the Klipsch R-50M, I'd suggest looking at the very similar RP-500M II. It looks about the same, but it's in Klipsch's higher tier (reference premiere, instead of just reference), so it'll have better innards. The crossovers, wiring and such. I mention this because while it has a higher MSRP, it looks like there are a few deals on it right now which put it around the same price point. Musicdirect has an open box deal for $400, and they have a 60 day return policy. And Safe & Sound has them new on their amazon store for $390.
I'd recommend digging around for info on some of the audio forums. Searching a speaker or amp that you're interested in there to see what real people who've used them have to say. Sites like the stevehoffman forum, stereophile, audiokarma, et cetera. Professional reviews can be great, but remember that they're getting paid, and it's in their interests to have good relationships with the manufacturers. So it's always a good idea to see what real people have to say about a product whenever possible.
Good luck, homie. It's exciting getting new gear.