I made iso's of the 2 games I owned back when I had one, which was Tekken 4 and Soul Cal 2. I know defor was the resident 246 expert and had almost every game. I thought he had a website out there or a good thread here on the forums with all of nuances of the 2X6 systems. Do a search or pm Defor.
Kuze, you were right about the versions, I had to burn 2 Soul Calibur 2 Discs, but the second worked just fine.
Good to know you can recover the DVDs from the mame CHD